烷基-(S,Z)-2,4,5-三氨基戊酸鹽的合成優(yōu)化

化工論文編號:HG064  論文字?jǐn)?shù):11363,頁數(shù):24

目  錄
中文摘要 I
英文摘要 II
目錄 III
1. 緒論 1
 1.1 麥角硫因的概述 1
      1.2 麥角硫應(yīng)的分布 2
 1.3 麥角硫因的抗氧化性 4
 1.4 麥角硫因的其他生物學(xué)功用 6
 1.5 麥角硫因的新陳代謝 6
 1.6 麥角硫因的提取和分離 7
 1.7 麥角硫因的生物化學(xué) 8
2. 實(shí)驗(yàn)部分 11
 2.1 麥角硫因的化學(xué)合成 11
 2.2 實(shí)驗(yàn)步驟和現(xiàn)象 12
 3. 結(jié)果與討論 15
 3.1 核磁共振圖譜的分析 15
 3.2 紅外圖譜的分析 17
4．總結(jié)與展望 18
致謝 19
參考文獻(xiàn) 20

摘 要：麥角硫因是自然界中一種稀有天然氨基酸，在機(jī)體內(nèi)具有重要的生理活性，但是不能從在機(jī)體內(nèi)合成，因此只能從飲食中獲得。國外研究表明它在生物體內(nèi)可起抗氧化劑作用并且安全，無毒，是一種理想的天然抗氧化劑。本文以L-組氨酸甲酯二鹽酸鹽為原料，苯甲酰氯、濃鹽酸等作輔料，在四氫呋喃、甲醇等多種溶劑中，合成麥角硫因。采用間歇-多步反應(yīng)法，逐步制得目標(biāo)產(chǎn)物麥角硫因。為提高產(chǎn)率，把一個步驟分成兩步完成，在每一步后，進(jìn)行產(chǎn)物的核磁共振譜圖和紅外光譜圖的測定，以此和目標(biāo)產(chǎn)物進(jìn)行比對，排除可能發(fā)生的副反應(yīng)，并且在同一條件下進(jìn)行不同反應(yīng)溫度和濃度的對比試驗(yàn)，調(diào)節(jié)不適當(dāng)?shù)姆磻?yīng)條件，從而達(dá)到對產(chǎn)物合成的優(yōu)化。

關(guān)鍵詞：麥角硫因；抗氧化劑；反應(yīng)溫度；核磁共振和紅外光譜圖。

Optimization synthetic of alkyl - (S, Z) -2,4,5 - 3 amino valerate
 
Abstract: L-Ergothioneine is a rare natural amino acid, important in vivo biological activity, but cannot synthesize from vivo synthesis, it can only be obtained from the diet. Overseas research shows that it can play an effect and safety role in vivo antioxidant, non-toxic, naturally and ideally. Methyl L-histidinol dihydrochloride as the raw material, benzoyl chloride, concentrated hydrochloric acid for accessories, in tetrahydrofuran, methanol and other solvents, synthesize ergothioneine. this article’s objective is to synthetize ergothioneine, using intermittent - multi-step reaction, and gradually obtained the target product ergothioneine. in order to improve the rate of production ,we separate one step to two steps .After every step ,we determinate the productions with the nuclear magnetic resonance(NMR) spectroscopy and IR spectra with the target production which is prepared in the previous time ,eliminating the side effects which may take place in the reaction. Under the same conditions, different reaction temperature and concentration of contrast test, we adjust the reaction conditions appropriate to achieve the optimization of the synthetic product.

Keywords：L-Ergothioneine; Antioxidant; Chemical reaction temperature; The nuclear magnetic resonance(NMR) spectroscopy and IR spectra.