Abstract: Asymmetric synthesis of important theoretical significance and potential applications. Catalytic asymmetric hydrogenation of which is particularly important. Chiral amino alcohols in asymmetric synthesis of optically active pharmaceutical intermediates and two broad purposes. Ring side acid has a stable structure, in which 3,4 - hydroxyl groups can be replaced by a variety of pro-nuclear grou. Chiral sulfur ligands square acylamino alcohol side on a combination of amino acids and alcohols advantages.The reaction of squaric acid and n-butyl is into dibutyl of squaric acid, then with (1S, 2R )-(+) or (1R, 2S )-(-)-2-amino-1,2-diphenyl ethanol by the reaction of a single chiral center side acylamino alcohol ligand. Purified, and then with NaHS solution reaction, on the sulfhydryl groups are sulfur-hand side of center acylamino alcohol ligand. Finally, in the presence of K2CO3 and acetone, sulfur amino alcohol ligand and between the three benzyl bromide under the conditions of reaction at 40 ℃, 2h sulfur product was obtained catalytic center of many chiral ligands.
Keywords: Asymmetric Synthesis; Asymmetric Catalysis; Chiral amino alcohol; Squaric acid; Between the three benzyl bromide; Sulfur chiral ligand
