摘 要：本文建立了紫外分光光度法定量測定輔酶Q10的分析方法，其定量檢測波長為275nm，在2.018～16.144μg/ml濃度范圍內線性良好，其線性回歸方程為： y = 0.0334x + 0.0127，相關系數R2=0.9999。用建立的方法定量分析了所制備的輔酶Q10微膠囊樣品的包埋率；用測量休止角的方法來測定微膠囊產品的流動性。實驗結果表明，所制備的微膠囊產品流動性良好，其中以冷凍干燥法制得的產品流動性最好，以噴霧干燥法制得的產品包埋率相對最高。本文還研究了DHA微膠囊的在不同pH值環境下的緩釋情況，繪制出不同pH條件下的動力學曲線，探究DHA微膠囊的釋放動力學機理，得出本實驗所用DHA微膠囊的釋放符合零級釋放動力學機理。
關鍵詞：微膠囊；包埋率；流動性；緩釋性；動力學曲線
Research on Properties of Microcapsules
Abstract: In this paper, quantitative analysis of coenzyme Q10 is carried out by UV spectrophotometry analysis, the wavelength of quantitative detection is 275nm, good linearity in the concentration range of 2.018 ~ 16.144μg/ml, the linear regression equation is: y = 0.0334x + 0.0127, the correlation coefficient R2 = 0.9999. We use the established method to quantitative analysis the embedded sample rate of the prepared coenzyme Q10 microcapsules; the liquidity of the prepared microcapsules is detected by measuring the angle, and the result showed that the liquidity of the prepared microcapsules is good., in which the product prepared by freeze-dring method has the best liquidity , and the one prepared by spray-drying has relatively highest embedding rate. This experiment also measured the control-release status of microencapsulated DHA under different pH values, so as to draw the kinetics curve under different pH values. Research into the mechanism of control-release kinetics of DHA microcapsules,the results showed that: In this experiment,the control-release of the DHA microencapsules is in line with the zero-level mechanism of release kinetics.
Keywords：Microcapsules;Embedding rate;Liquidity;Control release;Kinetics curve
