均勻試驗(yàn)及其在藥物研制優(yōu)化設(shè)計(jì)中的應(yīng)用

化工論文編號(hào):HG120  論文字?jǐn)?shù):18659,頁(yè)數(shù):38

目  錄
中文摘要 I
英文摘要 II
目錄 III
1. 緒論 1
 1.1 試驗(yàn)設(shè)計(jì)概述 1
 1.2 常用試驗(yàn)設(shè)計(jì)方法 5
 1.3 試驗(yàn)結(jié)果的數(shù)據(jù)處理方法 12
 1.4 試驗(yàn)設(shè)計(jì)在科學(xué)研究中的地位與意義 13
2. 均勻試驗(yàn)設(shè)計(jì) 15
 2.1 均勻試驗(yàn)設(shè)計(jì)的基本思想 15
 2.2 均勻試驗(yàn)設(shè)計(jì)的特點(diǎn) 15
 2.3 均勻試驗(yàn)設(shè)計(jì)表的構(gòu)造 16
 2.4 均勻設(shè)計(jì)表的特點(diǎn) 20
 2.5 均勻設(shè)計(jì)表的使用 21
 2.6 均勻設(shè)計(jì)與正交設(shè)計(jì)的比較 21
 2.7 均勻設(shè)計(jì)的步驟 22
 2.8 均勻設(shè)計(jì)的數(shù)據(jù)處理 22
3. 均勻設(shè)計(jì)的實(shí)際應(yīng)用 23
 3.1 藥物研制的試驗(yàn)條件的確定  24
 3.2 設(shè)計(jì)試驗(yàn)方案 24
 3.3 數(shù)據(jù)處理 25
 4.結(jié)果與討論 28
5．總結(jié)與展望 29
致謝 30
參考文獻(xiàn) 31
附錄 33

摘要：基于均勻設(shè)計(jì)具有實(shí)驗(yàn)次數(shù)少，因素的水平也可以適當(dāng)調(diào)整的特點(diǎn)，故它在尋找最佳實(shí)驗(yàn)條件、最佳配比等方面是選擇優(yōu)化條件的有力工具。均勻試驗(yàn)設(shè)計(jì)在藥學(xué)研究上的應(yīng)用十分廣泛，主要應(yīng)用于藥物合成、藥物分析、藥劑組方和藥理實(shí)驗(yàn)條件優(yōu)化等方面上。本文對(duì)試驗(yàn)設(shè)計(jì)的方法進(jìn)行了介紹，探討了均勻設(shè)計(jì)的特點(diǎn)，均勻設(shè)計(jì)表的構(gòu)造及其在藥物研制中的應(yīng)用。
 目的是優(yōu)化四君子湯提取的工藝條件。采用均勻設(shè)計(jì)法，以人參總皂甙和總多糖為指標(biāo)，探討了四君子湯的最佳提取工藝條件。優(yōu)化結(jié)果表明以己醇濃度10﹪，溶劑用量為藥材量的13倍，浸泡時(shí)間為14h，回流時(shí)間為2h為佳。得出的結(jié)論是均勻試驗(yàn)設(shè)計(jì)方法成功地實(shí)施了四君子湯提取方法的優(yōu)選，簡(jiǎn)單易行, 符合生產(chǎn)實(shí)際。
關(guān)鍵詞：均勻設(shè)計(jì)；正交設(shè)計(jì)；試驗(yàn)方案；藥物研制 ；優(yōu)化設(shè)計(jì)

Uniform design and its application in studying and optimizing new drugs
Abstract: Uniform design has the characteristics of fewer experimental times, and the level of factors which can be appropriately adjusted, so it is a powerful tool for choosing optimal conditions, especially in looking for the best experimental conditions, the best chosen ratio and so on. Uniform Design had a wide range of applications in pharmaceutical research, mainly used in areas such as drug synthesis, drug analysis, the Pharmacy Group and the Optimization pharmacological experiments. The article introduces the method of experimental design and discusses the feature and application of uniform design on studying new drugs, as well as the designing of uniform design form.
 The objective is to optimize the extracting technology of Si junzi Decoction. The optimal extracting technology of Si junzi Decoction was selected using Ginseng saponins and total polysaccharides as an index by a uniform design method. The results indicated that the optimal conditions were as follows：the concentration of alcohol was 10﹪(v／v)，the solvent quantity was 13 times as much as the drug quantity，the soak time was 14 hours and the reflux time was 2 hours. We can obtain the conclusion that the optimized procedure of uniform design succeeded in the optimal extracting technology of Si junzi Decoction. It is simple and easy to do, and suitable for practical production.
Key word: uniform design; orthogonal design; experimental scheme; studying drugs；optimum design