甲基-2，3-O-異亞丙基-5-脫氧-β--D-呋喃核糖苷的合成

化工論文編號:HG142  論文字?jǐn)?shù):9056,頁數(shù):25

目  錄
中文摘要....................................................................I
英文摘要...................................................................II
目錄......................................................................III
 1. 緒論....................................................................1
 1.1 選題的背景與意義....................................................1
 1.2 呋喃及其衍生物的應(yīng)用................................................1
 1.3 文獻(xiàn)合成方法綜述....................................................2
 1.4 研究的基本內(nèi)容與擬解決的主要問題....................................3
 1.5 合成路線選擇........................................................4
 1.6 本章小結(jié)............................................................4
 2. 實驗部分................................................................5
 2.1 實驗試劑............................................................5
 2.2 實驗原料的物性......................................................5
 2.3 實驗儀器............................................................7
 2.4分析儀器 ...........................................................7
 2.5 實驗裝置圖..........................................................9
 2.6實驗步驟............................................................11
 2.7 本章小結(jié)...........................................................13
 3. 結(jié)果與討論............................................................14
 3.1實驗結(jié)果............................................................14
 3.2實驗討論...........................................................17
  3.3 本章小結(jié)..........................................................18
 4. 結(jié)論 .................................................................19
致謝.......................................................................20
參考文獻(xiàn)...................................................................21

摘 要：首先以D-核糖為起始原料，2,2-二甲氧基丙烷作為保護(hù)基原料，得到甲基-2,3-O-異亞丙基-β-D-呋喃核糖苷，然后用甲苯黃酰氯保護(hù)得到甲基-2,3-O-異亞丙基-5-o-甲苯磺酰基-β-D-呋喃核糖苷，繼續(xù)用硼氫化鈉還原得到甲基-2,3-O-異亞丙基-5-脫氧-β-D-呋喃核糖苷。經(jīng)過對原有合成路線的優(yōu)化改進(jìn)，此反應(yīng)操作方便簡單，重復(fù)性好，反應(yīng)時間短，反應(yīng)平和，產(chǎn)物易純化，在工業(yè)上有較大的應(yīng)用價值。

關(guān)鍵詞： D-核糖;甲基化;乙酰化;呋喃核糖苷

Abstract:  Methyl-2,3-O-isopropylidene-β-D-ribofuranoside was prepared from D-ribose protected by 2,2-dimethoxypropane. Methyl-2,3-O-isopropylidene-5-o-trifluoromethanesulfonyl -β-D-ribofuranoside glucoside was synthesized from methyl-2,3-o-isopropylidene-β-D- ribofuranoside and TSCl. Then Methyl-2,3-o-isopropylidene-5-o-trifluoromethanesulfonyl-β- D-ribofuranoside glucoside was reduced by NaBH4 to get methyl -2,3-O- isopropylidene-5- deaeration - beta -D- ribofuranose glucoside. Through the optimization and improvement of original process  , this reaction is simple, duplicates well, reaction time is short, preceeds smothly,  and the product is easy to purify, has the wided application in the industry. 

Keywords：D- ribose; methyl; acetylize; furan ribofuranose