Abstract: Chiral secondly Alcohols is many drugs, pesticides and functional materials of the importance of organic synthesis intermediates, Chiral secondly Alcohols was chiral alcohols high enantiomeric excess percentage (e.e. value) of one of the important ways of chiral amino alcohols ligand catalysts Reduction of prochiral ketone access. In this paper, the inspection on the basis of relevant information on the asymmetric catalytic reduction reaction of new progress.
In order to find high performance catalyst ligand, Based on catalytic center ligands in asymmetric catalytic reduction reaction of synergies, SIN available chiral alcohols e.e. higher value, we were using the (1S, 2R )-(+) and (1R, 2S )-(-)- 2-amino-1 ,2-phenyl ethanol two chiral between two sources with benzyl bromide reaction optimal reaction conditions in ethanol solution, in 70° C, with KI as catalyst K2CO3 agent for the first synthesis of hydrogen containing two catalytic center ligand, by silica gel column chromatography in the colorless crystal, Yield76.5% and80.3%. Product by IR, HNMR, and H is confirmed. In synthesis pairs enantiomers, their spectroscopic properties, and the melting point than the rotation, and other physical constants are very good test.
Natural ephedrine (-) as chiral source, similar to the above reaction of the same good results.
