羧甲基殼聚糖水凝膠在應(yīng)用藥物管制

論文編號(hào):HG308   論文字?jǐn)?shù):24658,頁數(shù):37

摘要
 以戊二醛為交聯(lián)劑制備了一系列羧甲基殼聚糖水凝膠。重點(diǎn)研究水凝膠的溶脹率、PH敏感性和各因素對(duì)羧甲基殼聚糖水凝膠溶脹性能的影響，如羧甲基殼聚糖脫乙酰度對(duì)水凝膠溶脹率的影響、交聯(lián)劑的濃度對(duì)水凝膠溶脹率的影響，并以水楊酸為模型藥物進(jìn)行了釋藥性能研究。實(shí)驗(yàn)結(jié)果表明羧甲基殼聚糖的脫乙酰度、交聯(lián)劑用量對(duì)水凝膠溶脹率的影響較大。PH=3.0時(shí),水凝膠收縮,而PH=1.0 ,5.0 ,7.4 ,9.0時(shí) ,水凝膠溶脹,且在堿性條件下水凝膠的溶脹率遠(yuǎn)大于酸性條件下的溶脹率。包埋在此水凝膠中的水楊酸釋放隨載藥介質(zhì)的PH值和水凝膠半徑大小的變化而顯著不同,PH=1.0條件下載藥的水凝膠的釋藥率大于PH=7.4 ,12.0條件下的釋藥率 ,且水凝膠的半徑越大 ,釋藥速度和釋藥率也越大。

關(guān)鍵詞：羧甲基殼聚糖水凝膠 , 溶脹率 , 水楊酸 , 控制釋放

Title:Carboxymethyl chitosan hydrogels in the application of drug control
Abstract：
Hydrogels based on carboxymethyl chitosan(CMCTS) were synthesized by using glutaraldehyde as cross-link agenl. Focus on the swelling rate, pH-sensitivity and various factors on swelling properties of carboxymethyl chitosan hydrogel,such as the effects of the degree of deacetylation of CMCTS on the swelling behaviors of hydrogels, the effects of crosslinker concentration on the swelling behaviors of hydrogels ,and salicylic acid as a model for the release of drug have been studied.The results show that the two factors related above regulate their swelling behavior.At PH=3.0,the hydmgel shfinked most while swelled at PH=1.0,5.0,7.4,9.0.In general the swelling ratio(SR) of this hydrogel in alkaline solution is much larger than that in acidic solution.The release behavior of salicylic acid(SA) entrapped in the hydrogels was of distinctly difference with the changes of PH value of loading medium and the semidiameter of the hydrogels.The release of salicylic acid in CMCT hydmgel in the mediumof PH=1.0 was much quicker in PH=7.4,12.0,and the release speed and release ratioincrease with the particalsize.
   

Keywords:carboxymethyl chitosan hydrogels,swelling rate,salicylic acid,
controlled release

 
 
 目           錄
1.文獻(xiàn)綜述 1
1.1引言 1
1.2殼聚糖 1
1.3甲殼素/殼聚糖及其衍生物的制備研究 2
1.3.1甲殼素的制備 3
1.3.2殼聚糖的制備 3
1.3.3殼聚糖衍生物的制備 4
1.4.殼聚糖在生物醫(yī)藥中的應(yīng)用 5
1.5羧甲基殼聚糖的功能性質(zhì)與結(jié)構(gòu)關(guān)系 8
1.5.1取代基團(tuán)特性 8
1.5.2取代位置 8
1.5.3取代程度（Degree of substitute,DS） 8
1.5.4取代分布 9
1.5.5聚合度及其分布 9
1.6羧甲基殼聚糖的制備 9
l.6.1 N，O-羧甲基殼聚糖的制備 9
1.6.2羧甲基殼聚糖的水溶液性質(zhì) 10
1.6.3羧甲基殼聚糖的應(yīng)用 11
1.7水凝膠 14
1.7.1水凝膠的分類 15
1.7.2高分子水凝膠的制備 15
1.7.3水凝膠的應(yīng)用 16
1.8本課題的意義和創(chuàng)新點(diǎn)： 18
1.8.1 選題的意義 18
1.8.2 創(chuàng)新點(diǎn) 18
2.實(shí)驗(yàn)部分 20
2.1試劑和儀器 20
2.2羧甲基殼聚糖的制備 20
2.3羧甲基殼聚糖水凝膠( CMCTH)的合成 21
2.4水凝膠溶脹率的測(cè)定 22
2.5水凝膠結(jié)構(gòu)表征 22
2.6羧甲基殼聚糖脫乙酰度對(duì)水凝膠溶脹率的影響 23
2.7交聯(lián)劑的濃度對(duì)羧甲基殼聚糖水凝膠溶脹率的影響 23
2.8水楊酸的吸附與釋放 23
3. 結(jié)果與討論 24
3.1羧甲基殼聚糖水凝膠溶脹動(dòng)力學(xué) 24
3.2羧甲基殼聚糖水凝膠的PH敏感性 24
3.3羧甲基殼聚糖脫乙酰度對(duì)水凝膠溶脹率的影響 25
3.4交聯(lián)劑的濃度對(duì)羧甲基殼聚糖水凝膠溶脹率的影響 26
3.5水楊酸在該水凝膠中的吸附和釋放研究 27
3.5.1不同PH下水楊酸的控制釋放 27
3.5.2水凝膠的半徑大小對(duì)于該控制釋放體系的影響 28
3.6紅外表征 29
4. 結(jié)論 30
致    謝 31
參考文獻(xiàn) 32