丁醚脲-脲的制備工藝

制藥工程論文編號(hào):ZY040    論文字?jǐn)?shù):7564,頁數(shù):29

目  錄
中文摘要 I
英文摘要 II
目錄 III
1. 緒論 1
 1.1  丁醚脲的簡介 1
 1.2  丁醚脲-脲的簡介 5
2. 實(shí)驗(yàn)部分 7
 2.1  試劑和儀器 7
 2.2  實(shí)驗(yàn)合成 8
3. 結(jié)果與討論 12
 3.1  2,6-二異丙基苯胺的氣相色譜分析 12
 3.2  4-溴-2,6-二異丙基苯胺的氣相色譜分析 14
 3.3  4-苯氧基-2,6-二異丙基苯胺的氣相色譜分析 15
 3.4  丁醚脲-脲的液相色譜分析 17
 3.5  丁醚脲-脲的紅外光譜分析 19
 3.6  實(shí)驗(yàn)探討 21
4．總結(jié)與展望 22
 4.1  總結(jié) 22
 4.2  展望 22
致謝 23
參考文獻(xiàn) 24

 摘 要：丁醚脲是一種新型硫脲殺蟲，殺螨劑。丁醚脲對(duì)菜青蟲、小綠葉蟬等多種害蟲、害螨均有較好的防治效果。丁醚脲-脲是殺蟲劑丁醚脲中的一種雜質(zhì)。為了更好的的檢測出丁醚脲中的丁醚脲-脲，制備高純度的丁醚脲-脲作為參照物。本論文以2,6-二異丙基苯胺為原料，與溴反應(yīng)制備4-溴-2,6-二異丙基苯胺；在氫氧化鉀和氯化亞銅的作用下4-溴-2,6-二異丙基苯胺再與苯氧基置換得到4-苯氧基-2,6-二異丙基苯胺，利用減壓蒸餾提純4-苯氧基-2,6-二異丙基苯胺；將提純的4-苯氧基-2,6-二異丙基苯胺依次與固體光氣和叔丁胺反應(yīng)生成N-叔丁基-N’-(2,6-二異丙基苯基-4’-苯氧基)尿素，即丁醚脲-脲，純度為99.43%。

關(guān)鍵詞：丁醚脲；丁醚脲-脲；2,6-二異丙基苯胺；固體光氣

Abstract: Diafenthiuron was one new thiourea insecticide and miticide. Diafenthiuron can control and kill Pieris rapae, leafhopper and other pests, mites. Diafenthiuron-urea was an impurity in the preparation of Diafenthiuron. In order to detect Diafenthiuronur-ea in Diafenthiuron better. Prepared high-purity Diafenthiuron-urea as a reference. In this article, Diafenthiuron-urea was synthesized from 2,6–Diisopropylaniline. Prepared 4-bromo-2,6-Diisopropylaniline with bromine; 4-bromo-2,6-Diisopropylaniline was converted to 4-phenol-2,6–Diisopropylaniline by treatment with phenol, cuprous chloride and potassium hydroxide in xylene, and got the pure 4-phenol-2,6–Diisopropylaniline through vacuum distillation; Under the action of triphosgene and tert-butylamine, the pure 4-phenol-2,6–Diisopropylaniline can converted to N-tert-butyl-N’-(2,6-diisopropylphenyl- 4'-phenoxy) urea, also called Diafenthiuron–urea，a purity of 99.4%.

Keywords：Diafenthiuron; Diafenthiuron - urea; 2,6 - Diisopropylaniline; triphosgene