非諾貝特酸膽堿的制備

制藥工程論文編號:ZY041    論文字數:12346,頁數:26

目  錄
中文摘要 I
英文摘要 II
目錄 III
1. 緒論 1
 1.1  研究的背景 1
 1.2  研究的意義 1 
 1.3  膽堿簡介 3
 1.4  非諾貝特酸簡介 4
 1.5  膽堿鹽及其合成方法介紹 4
2. 實驗部分 8
    2.1  實驗原理 8
 2.2  實驗試劑 10
 2.3  實驗儀器   10
 2.4  實驗基本操作 10
 2.5  產物分析 10
3. 結果與討論 10
 3.1  實驗結果 10
 3.2  實驗討論 11
4．總結與展望 15
致謝 17
參考文獻 18
附錄 20

摘要：非諾貝特酸膽堿是一種新型降脂藥物。本論文提出一條新的制備非諾貝特酸膽堿的原料路線，即三甲胺和非諾貝特酸在異丙醇作溶劑條件下，首先酸堿中和反應成鹽，然后該鹽在H+的催化下再與環氧乙烷反應生產氫氧化膽堿鹽。這是一個自催化反應。實驗中，我們詳細研究了反應物配比、溶劑種類、反應時間、加料時間及加料速度等因素對產品純度及產率的影響。在最佳工藝條件下，得到精制后產品質量20.93g，最終收率達95%以上。產物結構由IR得到證明，產品用HPLC進行分析，純度為99.80%。
 
關鍵詞：非諾貝特酸膽堿；膽堿；自催化；有機合成

Abstract：The Choline Fenofibrate Acid is a new type of lipid-lowering drugs.In this study,a new material route for preparation of Choline Fenofibrate Acid was provided. That is using Trimethylamine and Fenofibrate Acid to prepare salt in the Isopropanol, then using the salt and Ethylene Oxide to synthesize Choline Hydroxide salt and H+ as catalyst. This is a selfcatalysis reaction. In the experimental, the conditions of synthesis such as proportions, kinds of solvents, reaction time, feeding times, feeding speeds and etc.were investigated in detail and see the impact on the purity and the yield. In the best conditions,the quality of refined product is 20.93g, and the yield was reached more than 95%.The structure of the product was confirmed by IR,and the product was analysised with HPLC and the purity was morn than 99.8%.
 
Keywords: Choline fenofibrate acid; Choline; Selfcatalysis;Organic synthesis