金剛烷胺的合成研究

制藥工程論文編號:ZY052    論文字數:10075,頁數:26

目錄
中文摘要 I
英文摘要 II
目錄 III
1 緒論 1
 1.1 前言 1
 1.2 背景 1
 1.3 金剛烷胺的合成方法 3
 1.4 立題依據 6
2 實驗部分 7
 2.1 實驗試劑和儀器 7
 2.2 實驗方法 7
 2.3 實驗內容 7
 2.4本章小結 9
3 實驗結果與討論 10
 3.1 金剛烷溴代的影響因素討論 10
 3.2 溴代金剛烷與尿素反應的影響因素與討論 12
4 實驗總結 17
 4.1 溴代金剛烷影響因素討論 17
 4.2 金剛烷胺生成反應影響因素討論 17
 4.3 最佳工藝條件 18
 4.4 實驗注意事項 18
5 展望 19
致 謝 20
參考文獻 21

摘 要：金剛烷的衍生物金剛烷胺又名三環癸烷，在醫藥方面有廣泛的應用。最主要應用于抗病毒方面�？捎糜陬A防治療甲型流感病毒引起的上呼吸道疾病，也可用于治療腦血管障礙癥和老年癡呆癥。
 金剛烷胺廣泛應用于醫藥領域。本文主要介紹了以金剛烷為原料合成金剛烷胺的合成。首先通過金剛烷與乙腈的反應合成金剛烷胺，其次采用先鹵化后胺化的方法得到產物，在實驗過程中通過改變原料的摩爾比，反應的初始溫度以及是否使用石蠟作為催化劑，然后通過對比對合成路線進行優化。
關鍵詞：金剛烷；金剛烷胺；合成；溴化；尿素

Abstract: The amantadine, the derivative of adamantine, also names tricycle decane, and is widely applicated in medicine, most mainly on the anti-viral aspect. Amantadine hydrochloride is used as anti-viral medicine for a long time in clinical to treat the disease of upper respiratory tract infection caused by flu virus,and also used to treat the blood vessel of brain barrier sickness and old age dementia.
 Amantadine drug has been widely used in pharmaceutical fields. In this paper amantadine was synthesized using adamantane as a starting material. The first method for synthesis of amantadine is that adamantine reacted with acetonitrile in one step, the second method is halogenation of adamantane followed by amination. The reaction conditions were optimized, by change the material’s molar rate and the starting temperature and usage of olefin.
Keywords: adamantane; amantadine; synthesis; bromine; urea