Abstract Objective The complication rate using the full range of frozen and surgical treatment, by contrast to the same pathological type of liver cancer patients, patients satisfaction, patients 1 year and 3-year survival rate, select the more favorable treatment to patients. Methods Suffering from advanced liver cancer stay in hepatobiliary surgery needed to treat patients according to the selected treatment program into a full range of cryotherapy (freezing group) and conventional surgery group (surgery group), records were compared between the two groups of cases of postoperative complications occurred,follow-up investigation in patients 1 year and 5-year survival rate, evaluation of more effective treatment. Results (1) Compared the clinical data, including gender, incidence of origin of hepatitis B surface antibody, pathological stage of patients in the two groups, the difference was not significant (p> 0.05), showing that the two sets of clinical data was no significant difference,and was comparable. (2)The same pathological type, severity of disease is considerable in patients with advanced surgery and cryotherapy, two groups of patients with complication rate differences, cryotherapy Overall complication rate is lower than the surgical group. P < 0.05, the difference was statistically significant (3)Accept the freezing treatment, patient satisfaction with surgery than the conventional surgery group; P < 0.05, the difference was statistically significant. one year survival in two groups of patients is quite frozen in patients treated with 3-year survival rate is higher than the surgery alone group.. (4) Compared to conventional surgery, cryotherapy has the low incidence of complications, P <0.05, which difference has statistically significant. With long-term survival and quality of life, the cryotherapy is worthy promoting on patients with advanced hepatocellular carcinoma in the clinical treatment. Conclusions With advanced hepatocellular carcinoma in patients with a full range of cryotherapy and to take timely, safe and effective care can effectively prevent and reduce complications and improve patient and long term survival and quality of life, is a safe and effective treatment. Keywords Full range of cryotherapy; Surgery; With advanced hepatocellular carcinoma; Complications Paper type: clinical study 目 錄 摘要………………………………………………………………………………… 1 前言………………………………………………………………………………14 1.1研究背景及意義 ………………………………………………………………14 1.2研究目的及目標 ………………………………………………………………15 1.2.1研究目的…………………………………………………………………… 15 1.2.2研究目標…………………………………………………………………… 16 1.3關鍵詞及定義………………………………………………………………… 16 1.3.1全方位冷凍治療…………………………………………………………… 16 1.3.2手術治療…………………………………………………………………… 16 1.3.3中晚期肝癌……………………………………………………………… 16 1.3.4并發癥……………………………………………………………………… 16 1.4文獻回顧……………………………………………………………………… 17 1.4.1中晚期肝癌的判斷標準…………………………………………………… 17 1.4.2 中晚期肝癌研究現狀……………………………………………………… 17 1.4.3中晚期肝癌治療方法……………………………………………………… 17 1.4.4 肝癌的手術治療效果…………………………………………………… 18 2研究設計與方法…………………………………………………………………20 2.1研究設計………………………………………………………………………20 2.2研究對象………………………………………………………………………21 2.3研究步驟………………………………………………………………………21 2.4研究工具及方法………………………………………………………………21 2.5資料分析………………………………………………………………………22 3結果與分析………………………………………………………………………22 3.1試驗組與對照組的臨床資料的分析…………………………………………22 3.2兩組術后并發癥相關分析………………………… 23 3.3兩組患者術后隨訪結果對比………………………23 4討論 …………………………………………………………………………… 25 4.1 冷凍治療肝癌…………………………………………………… 25 4.1.1 全方位冷凍治療中晚期肝癌……………………………………………… 25 4.1.2 冷凍治療的適應癥及禁忌癥……………………………………………… 25 4.1.3 冷凍治療術后并發癥及應對措施………………………………………… 25 4.2 手術治療肝癌………………………………… 25 5 結論………………………………………………………………………………27 6 致謝………………………………………………………………………………28 參考文獻………………………………………………………………………… 29 附表……………………………………………………………………………… 31
