年產(chǎn)1200噸阿司匹林的車間工藝設(shè)計

制藥工程論文編號:ZY085    論文字數(shù):15421,頁數(shù):52

目  錄
中文摘要............................................................. I
英文摘要............................................................ II
目錄............................................................... III
1. 緒論
 1.1  阿司匹林簡介 ............................................ 1
 1.2  阿司匹林生產(chǎn)情況............................................2
    1.3  阿司匹林工藝情況............................................3
    1.4  合成阿司匹林的各類催化劑優(yōu)缺點及催化劑選擇..................4
 1.5  研究課題概述................................................7
2. 阿司匹林車間工藝的設(shè)計計算
 2.1  設(shè)計內(nèi)容....................................................8
 2.2  合成工藝及精制過程..........................................8
 2.3  生產(chǎn)周期的確定..............................................8
 2.4  年產(chǎn)1200噸阿司匹林的物料衡算過程
 2.4.1  計算依據(jù)..............................................9
 2.4.2  物料衡算原理.........................................10
 2.4.3  酰化階段.............................................10
 2.4.4  冰水冷卻結(jié)晶階段.....................................12
 2.4.5  乙醇結(jié)晶階段.........................................13
 2.4.6  溫水重結(jié)晶階段.......................................13
 2.5  熱量衡算
 2.5.1  熱量衡算概述.........................................14
 2.5.2  熱量衡算方程式及各部分熱量具體計算...................14
 2.5.3  酰化反應(yīng)階段Q1（Q4）的計算............................15
 2.5.4  Q3的計算 .............................................16
 2.5.5  Q5+Q6的計算...........................................21
 2.5.6  加熱蒸汽量q的計算....................................22
 2.5.7  冰水結(jié)晶階段熱量衡算.................................22
 2.5.8  乙醇結(jié)晶階段熱量衡算 ................................23
 2.5.9  溫水結(jié)晶階段熱量衡算 ................................24
 2.6  釜體設(shè)計
 2.6.1  確定酰化釜的容積.....................................25
 2.6.2  確定筒體和封頭型式...................................26
 2.6.3  確定筒體和封頭直徑...................................26
 2.6.4  確定筒體高度.........................................26
 2.6.5  確定夾套直徑.........................................27
 2.6.6  確定夾套高度.........................................27
 2.6.7  內(nèi)筒及夾套的受力分析.................................27
 2.6.8  計算夾套筒體、封頭厚度...............................27
 2.6.9  計算內(nèi)筒筒體厚度.....................................28
 2.6.10  確定內(nèi)筒封頭厚度....................................28
 2.6.11  確定冰水結(jié)晶釜的容積................................29
 2.6.12  確定結(jié)晶釜各參數(shù)....................................29
 2.6.13  確定乙醇結(jié)晶釜的容積................................32
 2.6.14  確定乙醇結(jié)晶釜各參數(shù)................................32
 2.6.15  確定溫水結(jié)晶釜的容積................................32
 2.6.16  確定溫水結(jié)晶釜各參數(shù)................................32
 2.7  氣流干燥器的設(shè)計
 2.7.1  設(shè)計條件.............................................32
 2.7.2  水分蒸發(fā)量W..........................................33
 2.7.3  空氣消耗量L..........................................33
 2.7.4  干燥器直徑D..........................................34
 2.7.5  干燥管高度Z..........................................34
 2.8  旋風分離器的選擇與設(shè)計
 2.8.1  設(shè)計條件.............................................36
 2.8.2  確定旋風分離器進口氣速...............................36
 2.8.3  確定旋風分離器的工藝尺寸.............................36
 2.8.4  旋風分離器的選型.....................................37
 2.9  過濾器的選型...............................................37
 2.10  貯罐容積的計算及選型
 2.10.1  醋酐貯罐............................................38
 2.10.2  冰水貯罐............................................38
 2.10.3  乙醇貯罐............................................38
 2.10.4  溫水貯罐............................................38
 2.10.5  87℃水貯罐..........................................39
 2.11  泵的選型..................................................39
3. 結(jié)果與討論
 3.1  物料衡算結(jié)果...............................................40
 3.2  熱量衡算結(jié)果...............................................40
 3.3  釜體及其他設(shè)備設(shè)計結(jié)果.....................................40
4．總結(jié)與展望.......................................................42
致謝................................................................43
參考文獻............................................................44
附錄................................................................46

摘 要：本文通過對幾種催化劑比較選擇使用一水合硫酸氫鈉為本次設(shè)計的生產(chǎn)工藝催化劑。用醋酐和水楊酸為原料，以一水合硫酸氫鈉為催化劑生產(chǎn)阿司匹林。工藝過程簡單，產(chǎn)品純度高，是阿司匹林生產(chǎn)的一條高產(chǎn)、優(yōu)質(zhì)、低成本的有效途徑。設(shè)計了一個年產(chǎn)1200噸阿司匹林的生產(chǎn)車間,對物料、熱量、釜體、車間布置等進行研究。根據(jù)工藝特點確定反應(yīng)周期為每批14小時，每天1批。通過物料衡算得到每一種所需原料的質(zhì)量；通過熱量衡算得到所需傳遞的熱量；然后根據(jù)衡算結(jié)果進行釜體設(shè)計,確定為6的反應(yīng)釜、10的兩個結(jié)晶釜和10的精制釜，設(shè)計內(nèi)容包含了釜體各部分尺寸、氣流干燥器、旋風分離器及車間布置等方面的設(shè)計，最后給出了生產(chǎn)工藝的反應(yīng)流程簡圖、車間布置圖和反應(yīng)釜體裝配圖。
關(guān)鍵詞：阿司匹林；物料衡算；熱量衡算；釜體設(shè)計；車間布置

Abstract: this paper choose Sodium bisulfate monohydrate as the production catalyst for this design through comparison of a few catalysts. take the Sodium bisulfate monohydrate as catalyst and use the Acetic Anhydride, Salicylic acid as raw materials, to produce Aspirin. The craft process for Aspirin is a valid path of high produce, superior quality and low cost for the process is simple and product purity is high. We Designed a Production workshop for Aspirin of 1200 t/a for annual output, and studyed the materials, calories, body, the workshop decoration etc. According to the the process characteristics, we definite the reaction cycle for 14 hours each time, everyday 1 pass. According to the results of balance, We design the kettle ,also definite a Reactor of 6 cubic meters, two Crystalline kettle of 10 cubic meters, and a Refining Crystalline kettle of 10 cubic meters, though Mass Balance, quality that materials needed each time, and though Heat Balance, calories that needed to deliver, the design also included the body each parts of sizes and air dryer、cyclone and workshop layout, and so on. Finally, a flow chart of the reaction, a workshop layout diagram and a reaction kettle assembling drawing are given.
Keywords：Aspirin; Mass; Balance;  Heat Balance;  Kettle Design;  Workshop Layout