反應精餾制備三氟乙酸乙酯

制藥工程論文編號:ZY108    論文字數:10556,頁數:26

目  錄
中文摘要 Ⅰ
英文摘要 Ⅱ
目錄 Ⅲ
1. 緒論 1
   1.1  三氟乙酸乙酯的介紹 1
   1.2  項目概況 1
   1.3  反應精餾技術的發展史 2
       1.3.1  反應精餾技術的應用范圍 3
       1.3.2  反應精餾的操作工藝 3
       1.3.3  反應精餾的適用條件和工業要求 4
   1.4  本文的研究目的及研究內容 4
2. 實驗部分 5
 2.1  實驗試劑及實驗儀器 5
 2.2  實驗裝置 5
 2.3  制備原理 6
 2.4  反應精餾工藝流程 7
 2.4.1  三氟乙酸乙酯的物系性質 7
 2.4.2反應精餾合成三氟乙酸乙酯的工藝流程 8
 2.4.3產品的分析 9
 2.4.4計算公式 11
3. 結果與討論 12
 3.1實驗結果 12
 3.2催化劑用量的影響 13
 3.3三氟乙酸與乙醇摩爾比的影響 16
 3.4回流比的影響 17
 3.5小結 19
4總結和展望 21
致謝 22
參考文獻 23

摘 要：用傳統工藝制備三氟乙酸乙酯存在原料消耗大、能耗高、設備投資大、生產周期長、產品純度低和操作難度高等缺點。本文在對三氟乙酸乙酯生產體系各物性特點分析的基礎上，引入反應精餾技術，將化學反應和精餾分離結合在一個設備中同時進行，減少了設備投資，實現了連續化生產。以三氟乙酸、乙醇為原料，以濃硫酸為催化劑，對反應精餾法制備三氟乙酸乙酯的過程進行了實驗研究。著重考察了回流比、配料比、反應溫度、催化劑用量等因素對三氟乙酸乙酯的收率和產品中三氟乙酸乙酯含量的影響，并得出最佳的工藝條件。
關鍵詞： 三氟乙酸乙酯；三氟醋酸；乙醇；反應精餾

Abstract: Preparation of ethyl trifluoroacetate (TFAE) with traditional procedures had many disadvantages such as the raw materials waste, high energy consumption, amounts of equipment’s investments, long production period, difficult operation, etc. The reactive distillation method was introduced based on analysis of every component’s characteristics in the production system of TFAE. Combined reaction with distillation, the equipment’s investments was reduced and the production would be carried continuously. Preparation of TFAE through reactive distillation process had been researched, with trifluoroacetic acid and ethanol as raw materials, concentrated sulfuric acid as the catalyst. The experiments were focused on the reflux ratio, the mole ratio of components, reaction temperature, amount of catalyst and other factors influencing the yield and purity of TFAE, Finally, the optimum reaction conditions were obtained.
Key words: Ethyl trifluoroacetate; Trifluoroacetic acid; Ethanol; Reactive distillation