TAED在醋酐中的溶解度和結晶介穩區的研究

制藥工程論文編號:ZY109    論文字數:12643,頁數:38

 Ⅱ
 目  錄
中文摘要...........................................................I
英文摘要...........................................................II
目錄...............................................................Ⅲ
1. 緒論............................................................1
 1.1  TAED產品簡介...............................................1
  1.2  合成TAED的生產工藝.........................................1
 1.2.1  一步法合成TAED.........................................1
 1.2.2  兩步法合成TAED.........................................2
 1.2.3  合成TAED的催化方法選擇..................................3
 1.3  制備TAED的后續處理步驟......................................4
 1.4  結晶熱力學基礎..............................................4
 1.4.1  溶解度的概念............................................4
 1.4.2  溶解度的測定方法........................................5
    1.4.3  超溶解度的概念..........................................5
 1.4.4  超溶解度的測定方法......................................5
 1.4.5  介穩區的概念和介穩區寬度的計算方法......................6
 1.5  結晶動力學基礎知識..........................................7
   1.5.1  成核....................................................7
   1.5.2  晶體生長................................................8
 1.6 本課題研究的意義.............................................9
2. 實驗部分........................................................9
 2.1  實驗原材料和儀器............................................9
    2.1.1  實驗原材料..............................................9
    2.1.2  實驗儀器................................................9
  2.2  實驗操作過程................................................10
 2.2.1  飽和溶解度測定操作......................................10
 2.2.2  超溶解度的測定..........................................11
 III
 
3. 結果與討論......................................................11
 3.1  TAED在醋酐中的飽和溶解度....................................11
  3.2  TAED在醋酐中的結晶介穩區寬度................................12
    3.2.1  降溫速率對結晶介穩區寬度影響........................... 13
    3.2.2  攪拌速度對結晶介穩區寬度影響........................... 23
4. 總結展望........................................................31
致謝...............................................................32
參考文獻...........................................................33

摘要：四乙酰乙二胺( TAED)是一種性能優良的過氧化物漂白活化劑，結晶是TAED生產過程中的重要步驟之一，對TAED生產工藝的收率和質量指標有重要影響。溶解度和介穩區寬度是結晶過程的基礎研究內容之一。采用激光散射法測定了四乙酰乙二胺（TAED）在醋酐溶液中于不同降溫速率，攪拌轉速下的結晶介穩區寬度。并用最小二乘法對實驗數據進行回歸，得到不同的降溫速率下介穩區寬度△Tmax與濃度的關系，不同攪拌速率下介穩區寬度△Tmax與濃度的關系。結果表明：隨著降溫速率的增大，介穩區明顯變寬；隨著攪拌速率的增大，介穩區明顯變窄。
關鍵詞：四乙酰乙二胺；醋酐；結晶介穩區；激光散射法

Abstract：Tetraacetyl ethylenediamine (TAED) is a kind of good peroxide bleaching activators. Crystallization is an important step in the process of production, which has important influence on yield and quality of TAED in production process. Solubility and the metastable zone width is the one of the basic researchments in crystallization process. Using laser scattering method for measurements of crystallization metastable zone width and solubility of the teraacetyl ethylenenediamine (TAED) in acetic anhydride solution at different cooling rate, stirring speed. Measuring the metastable zone width △Tmax interface with concentration at different cooling rate, measuring the metastable zone width △Tmax interface with concentration at different stirring speed stability, Using least-square method of experiment data regression. The results show that, the high cooling rate increase the metastable zone width △Tmax, high stirring speed decrease the metastable zone width △Tmax.

Keywords： Tetraacetyl ethylenediamine；Acetic anhydride; Crystallization metastable zone;  Laser scattering method