Catalytic center with two Chiral amino alcohols ligand synthesis
Abstract: Chiral secondly Alcohols many drug ,pesticides and functional materials ,such as the importance of organic synthesis intermediates ,SIN was chiral alcohols high enantiomeric excess percentage (e. e. value) of one of the impways of chiral amino alcohols ligand catalysts Redution of prochiral ketone access .In this paper ,the inspection on the basis of relevant information on the asymmetric catalytic reduction reaction of new progress
In order to find high performance catalyst ligand ,Based on catalytic center ligands 、in asymmetric catalytic reduction reaction of synergies ,SIN available chiral alcohols e.e. higher value, we were using the(1S,2R)-(+)and (1S,2R) –(-)-2-amino-1,2-phenyl ethnol two chiral between two sources with benzyl bromide reaction optimal reaction conditions in ethanol solution ,in 70°C,with KI as catalyst K2CO3 agent for the first synthesis of hydrogen containing two catalytic center ligand , by silica gel column chromatography in the colorless crystal , Yield 80% and 85% .Product by IR,NMR,MS and H is confirmed .In synthesis pairs enantiomers ,their spectroscopic properties, and the melting point than the rotation ,and other physical constants are very good test.
Natural ephedrine (-) as chiral source , similar to the above reaction of same good results.
