Abstract: Chiral amino alcohol is a kind of the ligand, or catalyst with great potential for the development of catalytic asymmetric synthesis . They can asymmetric epoxidation of asymmetric carbon and nitrogen double bond reduction, asymmetric carbonyl compounds and organic reagent addition reaction, and so on…This paper is to hand a new multi-functional hands of the amino alcohol ligand synthesized from natural amino acids, and used mass spectrometry, infrared, NMR, elemental analysis, and other tests to determine the structure of the compound.
We use the (1 R, 2S )-(-) or (1 S, 2R )-(+)- 2 - amino-1，2 - diphenyl ethanol as chiral source，Acetonitrile or ethanol as solvent, K2CO3 for lashing acid, a small amount of KI as a catalyst, and 2,4,6 - Trimethyl--1,3,5 - three benzyl bromide or 1,3,5 - three benzyl bromide to synthesize three catalytic center ligand. And the melting point of products for polarimetry, Products by IR ﹑ 1 HNMR ﹑ MS identification to confirm its structure. In which the pair of enantiomers, the nature of its spectrum, and the melting point than the rotatory degree of physical constants, are very good verification.
