年產(chǎn)1000噸對甲砜基甲苯的車間生產(chǎn)工藝設(shè)計

制藥工程論文編號:ZY060    論文字?jǐn)?shù):13234,頁數(shù):36

 目錄

中文摘要……………………………………………………………………………I
英文摘要……………………………………………………………………………II      
目錄…………………………………………………………………………………III
緒論………………………………………………………………………………… 1
1．前言………………………………………………………………………………2
 1.1 對甲砜基甲苯的概述………………………………………………………2
 1.2 對甲砜基甲苯的合成方法比較…………………………………………  3
2．對甲砜基甲苯車間工藝的設(shè)計計算……………………………………………5
   2.1 設(shè)計內(nèi)容……………………………………………………………………6
 2.2對甲砜甲苯的生產(chǎn)工藝流程圖的確定…………………………………… 7
 2.3對甲砜基甲苯的生產(chǎn)周期的確定………………………………………… 7
 2.4 年產(chǎn)1000噸對甲砜基甲苯的物料衡算……………………………………8
 2.5 能量衡算……………………………………………………………………10
 2.6 設(shè)備選型………………………………………………………………… 18
3．車間布置的設(shè)計……………………………………………………………… 22
 3.1 設(shè)備布置原則………………………………………………………………22
 3.2設(shè)備布置設(shè)計的步驟……………………………………………………… 22
 3.3環(huán)境保護(hù)與安全措施……………………………………………………… 22
4. 三廢處理情況……………………………………………………………………23
 4.1 安全衛(wèi)生與勞動保護(hù)……………………………………………………… 23
 4.2車間安全措施要求………………………………………………………… 24
 4.3 衛(wèi)生措施…………………………………………………………………… 24
5. 討論與結(jié)果………………………………………………………………………29
 5.1 物料衡算結(jié)果……………………………………………………………… 29
 5.2 能量衡算結(jié)果……………………………………………………………… 29
 5.3 設(shè)備選型結(jié)果……………………………………………………………… 29
6.結(jié)論與展望……………………………………………………………………… 31
 致謝…………………………………………………………………………………21
 參考文獻(xiàn)……………………………………………………………………………32

摘要：對甲砜基甲苯是一種重要的醫(yī)藥化工原料，其傳統(tǒng)的制備工藝因“三廢”排放較多而易造成環(huán)境污染，本設(shè)計是先用對甲苯磺酰氯為原料，先用碳酸氫鈉和亞硫酸鈉為還原，通過不同的甲基化試劑進(jìn)行對比，最終用氯乙酸為甲基化試劑合成對甲砜基甲苯的制備方法；該設(shè)計合成工藝具有反應(yīng)條件溫和、操作安全、生產(chǎn)成本低、生產(chǎn)周期短、收率高、原料廉價易得、基本無“三廢”排放等綠色化學(xué)特點，更適合工業(yè)化生產(chǎn)。編制一份年產(chǎn)1000噸對甲砜基甲苯生產(chǎn)車間的工藝設(shè)計說明書，對物料、熱量、車間布置等進(jìn)行研究。根據(jù)工藝特點通過物料衡算得到每一種所需原料的質(zhì)量；通過熱量衡算得到所需傳遞的熱量；最后選出了甲基化反應(yīng)釜、真空干燥器、離心過濾器及車間布置等方面的設(shè)計、環(huán)境保護(hù)和安全措施，最后給出了生產(chǎn)工藝的反應(yīng)流程簡圖、車間布置圖。
關(guān)鍵詞：對甲砜基甲苯；對甲苯磺酰氯；物料衡算

 Abstract  Methyl sulfone toluene is an important chemical raw material medicine, the traditional preparation for the "three wastes" discharge more obviousness of environmental pollution, This design is the first use of tosyl chloride as raw material, first with sodium bicarbonate and sodium sulfite reduction,Methylation by different reagents were compared with chloroacetic acid as the final synthesis of a methylation reagent toluene sulfonyl Preparation;Its features is to tosyl chloride, anhydrous sodium sulfite, sodium bicarbonate, chloroacetic acid for the synthesis of raw materials; And on reaction conditions (including reagents, reaction time, reaction temperature, etc.) to improve and optimize. The new synthesis has mild reaction conditions, operational safety, low cost, short production cycle, high yield, raw materials cheaper, and basically no "three wastes" emissions such as green chemistry, it is more suitable for industrial production. The preparation of a 1000 tons of methyl sulfone toluene workshop process design specifications for materials, energy, kettle body, facility layout and other research. According to the technical characteristics of material balance obtained by each of the required quality of raw materials; through the heat balance to obtain the required heat transfer; Finally selected methylation reaction kettle, vacuum dryers, centrifugal filters and shop layout and other aspects of design, environmental protection and safety measures,given the reaction process simple production process maps, shop layout.
 
Key words  p-toluenesulfonic acid; p-toluene sulfonyl chloride; mass  balance;