殼聚糖-羧甲基纖維素溫敏凝膠的研制及其性能研究

制藥工程論文編號(hào):ZY066    論文字?jǐn)?shù):11342,頁數(shù):27

目  錄

中文摘要   I
英文摘要   II
目錄  
1  緒論    1
 1.1　凝膠   1
 1.2  高分子可降解材料   1
 1.3  研究內(nèi)容     3
2  實(shí)驗(yàn)部分   4
 2.1　實(shí)驗(yàn)試劑和儀器    4
 2.1.1　實(shí)驗(yàn)試劑   4
 2.1.2　實(shí)驗(yàn)儀器   4
 2.2　實(shí)驗(yàn)方法   5
 3  結(jié)果與討論   9
 3.1  原料的檢測   9
 3.2  CS-CMC溫敏凝膠的形成   12
 3.3  凝膠制備條件對(duì)凝膠形成的影響    13
 3.4  CS-CMC凝膠的處方優(yōu)化   15
 3.5  凝膠性能測試   16
4  總結(jié)與展望   20
致謝   21
參考文獻(xiàn)   22

摘要：本論文研究制備了能夠在生理?xiàng)l件下發(fā)生相轉(zhuǎn)化的殼聚糖-羧甲基纖維素凝膠。首先用酸度計(jì)法測得羧甲基纖維素鈉的取代度、雙突越滴定法測得殼聚糖的脫乙酰度，用烏氏粘度計(jì)測得羧甲基纖維素鈉、殼聚糖的粘均分子量，然后通過物理共混技術(shù)制備得到互穿網(wǎng)絡(luò)的殼聚糖-羧甲基纖維素水凝膠。通過對(duì)水凝膠制備條件的考察，優(yōu)選出具有快速響應(yīng)性的水凝膠，并對(duì)制得的凝膠進(jìn)行了確證和性能測定，如紅外光譜、溶脹度、透光率、相轉(zhuǎn)變溫度等。實(shí)驗(yàn)結(jié)果表明：當(dāng)殼聚糖溶液pH=4.6，質(zhì)量分?jǐn)?shù)為1% 羧甲基纖維素鈉溶液與等濃度殼聚糖溶液以0.8的體積比混合時(shí)，殼聚糖-羧甲基纖維素溶液在 41℃發(fā)生凝膠化，凝膠時(shí)間為1min。該凝膠在室溫或低于室溫時(shí)可保持液態(tài)，當(dāng)溫度達(dá)到體溫時(shí)可快速發(fā)生凝膠化，是一種可供醫(yī)療使用的智能水凝膠。
 
關(guān)鍵詞：殼聚糖；羧甲基纖維素鈉；溫敏性

Abstract: This thesis is to introduce the preparation of the chitosan-carboxymethyl cellulose (CS-CMC) hydrogel, which can occur the pHase transformation under pHysiological conditions. Firstly, the substitution degree of sodium carboxymethyl cellulose was measured by pH meter titration method, and the deacetylation degree of chitosan was measured by two abrupt titration method. The viscosity average molecular weights of sodium carboxymethyl cellulose and chitosan were determined by ubbelohde viscometer. And then the interpenetrating network hydrogel of chitosan-carboxymethyl cellulose (CS-CMC) was prepared by pHysical blending technology. The fast response hydrogel was obtained after the preparation condition study. Finally the characteristics identification and performance measurement of the obtained gel were carried out, such as infrared spectroscopy, swelling ratio, transmittance, pHase transition temperature, and so on. The results show that when the pH of CS solution reaches 4.6, 1% CMC solution mixed with equal concentrations of CS solution in the volume ratio of 0.8, the solution gelled at 41 ℃, the gel time was less than 1min. This hydrogel can be kept in the liquid at room temperature or below room temperature, while when the temperature reaches body temperature, it can quickly gelled, This hydrogel is smart and can be used in medical treatment.

 Key words:  Chitosan;  Carboxymethyl Cellulose;  thermo-sensitive