阿司匹林含量測定方法的比較

制藥工程論文編號:ZY099    論文字數:10407,頁數:24

目  錄
中文摘要 I
英文摘要 II
目錄 III
1. 緒論 1
 1.1 阿司匹林簡介 1
 1.2  阿司匹林含量測定方法現狀 2
2. 實驗部分 5
 2.1 紫外分光光度法測阿司匹林的含量 5
    2.1.1 紫外分光光度法原理 5
 2.1.2 儀器與試劑 5
 2.1.3 紫外分光光度法實驗部分 5
 2.2 高效液相色譜法測阿司匹林的含量 6
    2.2.1 高效液相色譜法原理 6
 2.2.2 儀器與試劑 7
 2.2.3 高效液相色譜法實驗部分 8
3. 結果與討論 10
 3.1 實驗結果 10
 3.1.1 紫外分光光度法測定結果 10
 3.1.2 高效液相色譜法測定結果 12
 3.2 實驗討論 15
4. 總結與展望 18
致謝 19
參考文獻 20

摘要：本論文采用兩種方法測定阿司匹林的含量。阿司匹林是一種使用非常廣泛、療效十分顯著的藥物，現其在中西結合治感冒制劑中普遍存在。阿司匹林主要有鎮痛、消炎、解熱、抗風濕及抑制血小板聚集等作用。非甾體類解熱鎮痛藥阿司匹林,素來被認為是較安全、較理想的對癥治療藥物。很多文獻采用酸堿滴定法測定阿司匹林的含量，該法實際應用具有局限性。本論文分別采用紫外吸收光譜法和高效液相色譜法測定阿司匹林的含量，并對兩種方法進行比較。結果表明，兩種方法均能準確測定阿司匹林的含量，但高效液相色譜法有著分離、分析的作用，應用范圍更廣,專屬性強，靈敏度高，測定結果不受其它成分的影響，故高效液相色譜法更能準確的測定阿司匹林的含量。

關鍵詞：阿司匹林；含量測定；紫外吸收光譜法；高效液相色譜法

Abstract : This article is about the determination of aspirin content with two methods. Aspirin is widely used, which can be commonly found in the combination of Chinese and Western rule prevailing cold preparations, and the effect is quitely obvious. For example, it plays a great role in analgesic, anti-inflammatory, antipyretic, antirheumatic and inhibittin platelet aggregation aspects. Non-steroidal anti-inflammatory drugs like aspirin, has always been regarded as relatively safe, a good symptomatic treatment drugs. The content determination of Aspirin is acid-base titration in many literatures, which is conditional in the actual application. In this article, we use two methods to determine the content of Aspirin. The two methods are UV spectrophotometry and HPLC. The results suggest that two methods all can determine the content of Aspirin. With comparison of the two methods, HPLC has separating and analytical functions, wider application of a strong specificity, high sensitivity Therefore HPLC is a more accurate determination of the content of aspirin. 

Keywords : aspirin; content determination; UV spectrophotometry; HPLC