DL－蘇式－對甲砜基苯基絲氨酸乙酯的拆分

生物工程論文編號:SW025  論文字數:9610,頁數:23 
目 錄
中文摘要 I
英文摘要 II
目 錄 III
1  緒論 1
 1.1  背景 1
 1.2  拆分方法 2
2  實驗部分 8
 2.1  儀器與試劑 8
 2.2  分析方法 8
 2.3  DL-蘇式-對甲砜基苯基絲氨酸乙酯拆分方法 9
3  結果與討論 13
 3.1  pH對化學成鹽法的影響 13
 3.2  還原反應中溫度的影響 13
 3.3  檢測數據 14
4  總結與展望 16
致謝 17
參考文獻 18

摘要:本文根據外消旋體的性質，通過在DL-蘇式-對甲砜基苯基絲氨酸乙酯鹽酸鹽的飽和溶液中加入D-蘇式-對甲砜基苯基絲氨酸乙酯鹽酸鹽晶種誘導D-蘇式-對甲砜基苯基絲氨酸乙酯鹽酸鹽結晶的方法和利用手性試劑酒石酸將外消旋體中的兩種對映體轉化為非對映異構體，再用氨水調節溶液pH，使D-蘇式-對甲砜基苯基絲氨酸乙酯的酒石酸鹽從溶液析出的方法使DL-蘇式-對甲砜基苯基絲氨酸乙酯得到拆分。

關鍵詞：外消體；DL-蘇式-對甲砜基苯基絲氨酸乙酯；手性拆分；

Chiral resolution of DL-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester compound

Abstract: According to raceme of nature, we have tow methods to separate the DL-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester. One is that adding a few of crystal of D-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester to the saturated solution of the raceme make the D-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester hydrochloride crystallize. The other method has the use of chiral reagents. The tartaric acid will change DL-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester into non-enantiomer. Ammonia was used to adjust the solution’s pH value to 7.8.That D-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester precipitate. The two methods for chiral resolution are feasible.
 Keywords: racemization; DL-threo-3-(4-methylsulfonylphenyl) serinate ethyl ester; chiral resolution