新型含有多聚苯剛性分子片段的生物堿衍生物的合成及其在不對稱反應中的應用研究

材料科學論文編號:CL105  論文字數:6767,頁數:22

目  錄
中文摘要 I
英文摘要 II
目錄 III
1. 緒論 1
 1.1  金雞納堿手性催化劑 1
 1.2  TPPh的應用 2
2. 實驗部分 5
 2.1 實驗藥品 5
 2.2 實驗儀器與設備 7
    2.3 實驗 9
 2.3.1 Model反應原料制備與表征 9
 2.3.2 催化劑合成原料中間體的制備與表征 12 
 2.3.3 催化劑的制備與表征 14
3. 結果與討論 16
 3.1 Model反應原料制備   16
 3.1.1 二苯亞胺的制備 16
 3.1.2 二苯亞胺甘氨酸特丁酯的制備 16
 3.2 催化劑合成原料制備 16
 3.2.1 四苯基苯甲酸的制備 16
 3.2.2 四苯基苯甲醇的制備 16 
 3.2.3 四苯基芐氯的制備 16
 3.3 催化劑的制備 17
4．總結與展望 20
致謝 21
參考文獻 22

摘要:本課題所研究的是含有多聚苯剛性分子片段的金雞納堿類手性催化劑。本實驗將一個多聚苯剛性分子片段（2，3，4，5-四苯苯基片段TPPh）連接到金雞納堿橋頭氮原子上來制備一系列催化劑，以二苯亞胺甘氨酸叔丁酯的不對稱烷基化反應為Model反應來考察其和橋頭氮聯芐基等小基團的催化劑相比對催化活性及對映選擇性的影響。
 本實驗合成了Model反應所需的二苯亞胺和二苯亞胺甘氨酸叔丁酯，以及合成催化劑所需的原料中間體——四苯基苯甲酸、四苯基苯甲醇、四苯基芐氯，并最終合成了目標催化劑。但由于時間關系，Model反應及其后工作目前正在進行中。關鍵詞：金雞納堿衍生物；TPPh；不對稱反應；α-氨基酸

Abstract: This paper focuses on the synthesis of cinchona alkaloid catalysts which contains rigid polybenzene moieties and their application in asymmetric catalytic reactions. Thus this experiment introduces a rigid polybenzene moiety (TPPh) to the bridge nitrogen atom of cinchona alkaloids to prepare a series of novel catalysts, which is further used as catalysts for the asymmetric alkylation of tert-butyl glycinate-benzophenone Schiff base. In the Model reaction, it investigates and compares the catalytic activity and enantioselectivity of the novel catalysts with other common catalysts derived from cinchona alkaloid with benzyl chloride or other small groups.
 This study of the Model  response to the diphenyl imine and diphenyl imine tert-butyl glycine, and the catalyst of raw materials for the intermediates - 4 phenyl acid, 4 phenyl benzyl alcohol, 4 phenyl benzyl chloride and finally gets the target catalysts. The experimental results of the novel catalyst in the Model reaction is not fully collected due to deficient time. However, It is now in progress in labs.
KeyWords：cinchona alkaloid derivatives;TPPh;asymmetric reaction;α-Amino Acids